Tablettose® 80
As a brittle substance, the compressibility of α-lactose monohydrate is closely related to the particle surface area before compression and the degree of fragmentation during compression. The larger the surface area of the powder, the higher the binding force between the particles, so the smaller the lactose particles, the better the compressibility. However, as the particles become smaller, the fluidity of lactose becomes worse, so grinding lactose monohydrate is not suitable for direct compression. Similarly, coarse granulated lactose has good fluidity but poor compressibility.
Based on the above reasons, Meggle is happy to develop the granule α-lactose Tablettose in the mid-1970s. He combines the fluidity of coarse granulated lactose with the good compressibility of finely ground lactose. Tablettose is made by continuous spray granulation. Water is sprayed onto the flowing finely ground lactose powder as a binder to form a liquid bridge that bonds the lactose powder together. After the water evaporates, the lactose fine powder still sticks together due to the liquid bridge, forming lactose particles. No amorphous lactose is produced in this process, so the product is pure alpha monohydrate lactose granules that are not easily absorbed by moisture.
Meggle's Tablettose® 80 is the earliest product of granular lactose, with a particle size of 0-630 μm. Tablettose® 80 is suitable for most low-dose prescriptions.
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